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    AngelBacked
    San DiegoUpdated November 2026

    Top 15 Angel Investors in San Diego (2026)

    San Diego is home to 361 angel investors and VCs in the AngelBacked database. The most active — ranked below by number of disclosed portfolio investments — include Houman Haghighi, Tracy Maziek and Killu Sanborn. Their portfolios concentrate in Health Care, E-commerce and Women Founded.

    1. 1
      Houman HaghighiPartner at Portfolium
      95 portfolio investments

      Notable investments: Solenica, Carbon Robotics, InovaDrone, CleverPet

      Health CareE-commerceWeb Browsers
    2. 2
      Tracy MaziekManaging Director at Oxford Finance LLC
      95 portfolio investments

      Notable investments: Bi02 Medical, Epic Healthcare Staffing, Cardiac Dimensions, Syros Pharmaceuticals

      Health CareHospitalsEyewear
    3. 3
      Killu SanbornManaging Director at N/A
      92 portfolio investments

      Notable investments: Bi02 Medical, Epic Healthcare Staffing, Cardiac Dimensions, Syros Pharmaceuticals

      Health CareHospitalsEyewear
    4. 4
      David HickmanManaging Director at N/A
      92 portfolio investments

      Notable investments: Bi02 Medical, Epic Healthcare Staffing, Cardiac Dimensions, Syros Pharmaceuticals

      Health CareHospitalsEyewear
    5. 5
      Christopher HerrSenior Managing Director at N/A
      92 portfolio investments

      Notable investments: Bi02 Medical, Epic Healthcare Staffing, Cardiac Dimensions, Syros Pharmaceuticals

      Health CareHospitalsEyewear
    6. 6
      Manav BhanotSoftware Development Engineer II at Amazon
      86 portfolio investments

      Notable investments: Vouch Financial, Chai, Notion, iPourIt

      Health CareE-commerceHome Automation
    7. 7
      Lucian IancoviciPartner and Managing Director, TPG Life Science Innovations at TPG
      85 portfolio investments

      Notable investments: PharmEasy, Gro Intelligence, Avanan, Albireo

      AdvertisingDiningHealth Care
    8. 8
      Swapna GuntakaSenior Staff Programmer Analyst at N/A
      80 portfolio investments

      Notable investments: Shadowfax, MoveInSync, Dunamu, Bell.ai

      Health CareBluetoothTraining
    9. 9
      John BonhardVice President at Blueprint Equity
      80 portfolio investments

      Notable investments: InSkin Media, Thread, Monica Vinader, SMARTASSISTANT

      AdvertisingE-commerceWomen Founded
    10. 10
      Richard TapalagaDirector at N/A
      79 portfolio investments

      Notable investments: Shadowfax, MoveInSync, Dunamu, Bell.ai

      Health CareTrainingWearables
    11. 11
      Yan LiuSenior Staff Engineer, Manager at N/A
      79 portfolio investments

      Notable investments: Shadowfax, MoveInSync, Dunamu, Bell.ai

      Health CareBluetoothTraining
    12. 12
      Rudy RehmFinance Partner at DCM Ventures
      78 portfolio investments

      Notable investments: Figure, EKuaibao, Eaze, Kespry

      AdvertisingWearablesMobile Technology
    13. 13
      Anna H. ChenBoard Member at Frazier Life Sciences
      75 portfolio investments

      Notable investments: Zeltiq Aesthetics, BARRX Medical, The CORE Institute, Lassen Therapeutics

      Health CareWellnessHealthcare Services
    14. 14
      Daniel EstesGeneral Partner at Frazier Life Sciences
      75 portfolio investments

      Notable investments: Zeltiq Aesthetics, BARRX Medical, The CORE Institute, Lassen Therapeutics

      Health CareRegenerative MedicineDrug Discovery
    15. 15
      Perry NisenIndependent Director, Chair of Science and Technology at N/A
      67 portfolio investments

      Notable investments: ENYO Pharma, Y-mAbs Therapeutics, NuCana, Histogenics

      Health CareGeneticsWomen Founded

    Methodology

    Investors are ranked by the number of disclosed portfolio investments recorded in the AngelBacked database of San Diego-based angels, VCs, and family offices. Rankings refresh as new investments are disclosed. Portfolio counts reflect publicly known deals and may understate an investor's full activity.

    Frequently Asked Questions

    Who is the most active angel investor in San Diego?

    Based on disclosed portfolio investments, Houman Haghighi (Portfolium) is the most active angel investor in San Diego in our database, with 95 portfolio investments.

    How many angel investors are in San Diego?

    AngelBacked's database includes 361 angel investors and VCs based in San Diego. This page ranks the 15 most active by portfolio size.

    What sectors do San Diego angel investors fund?

    The most common sectors among San Diego's top angel investors are Health Care, E-commerce, Women Founded, Biotech and Medical Device.

    How do I contact angel investors in San Diego?

    Each investor profile on AngelBacked includes verified contact details, portfolio companies, and sector focus. Warm introductions convert best, but a concise cold email referencing a relevant portfolio company also works — mention why your startup fits their investment pattern.

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    Browse All 361 San Diego Investors

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